李龙飞
李龙飞

姓名:李龙飞
职称/头衔:博士 检验中心副主任
所属科室:检验中心
从业年限:
技术专长:复发性流产及反复种植失败的免疫诊疗新策略

个人简介

  香港中文大学博士&博士后。深圳中山泌尿外科医院检验中心副主任,锦欣医疗科技创新中心PI,深圳市海外高层次人才。擅长领域:感染、代谢与妊娠并发症;内膜容受性标志物的开发与应用;社会任职:Current Medicinal Chemistry,International Journal of Molecular Medicine,Phytomedicine,Molecules, Cellular and Molecular Biology等杂志的特邀审稿人。

  研究方向:

  感染、代谢与妊娠并发症;内膜容受性标志物的开发与应用;干细胞研究与开发。

  学术成果:

  主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序):

  1. 国家自然科学基金,“TCP-2 肿瘤靶向肽在结肠组织上特异性靶标的分离鉴定及靶向传输免疫治疗药物的研究”,2017.01-2019.12,17.3 万元,负责人,已结题;

  2. 广东省自然科学基金面上项目,“IGF-1 通过上调子宫基质细胞丙酮酸激酶的表达促进蜕膜化的机制研究”,2019.10-2022.09,10 万元,负责人,在研;

  3. 深圳市自然科学基金面上项目,“滋养层细胞与母胎界面巨噬细胞极化的相互作用及机制研究”,2020-2023,20 万元,负责人,在研;

  4. 香港研究资助局优配研究基金,2140836,“肿瘤血管靶向肽(TCP-1 多肽)结合位点的分离及靶向治疗结肠癌的研究”,2014/01-2015/12,港币 64.9 万元,已结题,主要完成人;

  5. 香港中文大学知识产权转移项目,TBF14MED010, “结肠癌及其他消化道肿瘤诊疗的新制剂的研发”; 2014.1-2015.7, 港币 20 万元,已结题,主要完成人;

  6. 香港创新科技署第三层拨款项目及种子项目,6903572,“基于 TCP-1 多肽靶向传输 TNF α 和 IFN γ 治疗结肠癌的研究”,2013.9-2015.5, 港币 146 万,已结题,参加;

  7. 中国科学院昆明植物研究所,开放课题项目,P2009-KF03,“玉红牛肝菌中抗癌活性成分的研究”,2009.1-2010.12,人民币 10 万元,已结题,主要完成人。 8. 深圳市海外高层次人才 C 类,2018.06-2023.06.

  代表性研究成果和学术奖励

  一、期刊论文

  1. 第一作者或通讯作者论文

  1.1 .马静文,王琳琳,张燕,武娅娅,陈聪,吴娟花,连若纯,杨菁*,李龙飞﹡. 早孕期蜕膜免疫细胞谱及与妊娠的相关性。生殖医学杂志,2021(已接收)。

  1.2 .Li, L.F., G.G.L. Yue, B.C.L. Chan, Q. Zeng, Q.B. Han, P.C. Leung, K.P. Fung, J.K. Liu, and C.B.S. Lau, Rubinoboletus ballouii polysaccharides exhibited immunostimulatory activities through toll‐ like receptor‐4 via NF‐κB pathway. Phytotherapy Research, 2020.

  1.3.Wang, L.#, L. Li#(共同一作), C. Huang, L. Diao, R. Lian, Y. Li, S. Xiao, X. Hu, M. Mo, and Y. Zeng, Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment. Fertil Steril, 2019. 112(2): p. 250-257 e1.

  1.4.Longfei Li(第一作者), Linlin Wang, Chunyu Huang, Lianghui Diao, Yongnu Zhang, Xu Zhang, Jian Xu and Yong Zeng. Chronic hepatitis B infection alters peripheral immune response in women with reproductive failure. American Journal of Reproductive Immunology. 2019, 81(3): e13083.

  1.5.肖小龙,莫观,廉云,刘运蕾,李龙飞(通讯作者). 大分子灵芝多糖对非小细胞肺癌细胞增殖、迁移和侵袭能力的抑制作用。上海中医药大学学报,2018,32(6):56-60。

  1.6. Li, L.F.*(第一作者和通讯作者), Chan, R.L., Lu, L., Shen, J., Zhang, L., Wu, W.K., et al., Cigarette smoking and gastrointestinal diseases: The causal relationship and underlying molecular mechanisms, International Journal of Molecular Medicine. 34 (2014), 372-80.

  1.7.Li, L.F.(第一作者), Chan, B.C., Yue, G.G., Lau, C.B., Han, Q.B., Leung, P.C., et al., Two immunosuppressive compounds from the mushroom Rubinoboletus ballouii using human peripheral blood mononuclear cells by bioactivity-guided fractionation, Phytomedicine. 20 (2013), 3 1196-202.

  2. 既非第一作者又非通讯作者论文

  2.1.Li, Y., S. Yu, C. Huang, R. Lian, C. Chen, S. Liu, L. Li, L. Diao, U.R. Markert, and Y. Zeng, Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure. Fertil Steril, 2020. 113(1): p. 187-196 e1.

  2.2 .Zhang, H., C. Huang, X. Chen, L. Li, S. Liu, Y. Li, Y. Zhang, Y. Zeng, and L. Hu, The number and cytotoxicity and the expression of cytotoxicity-related molecules in peripheral natural killer (NK) cells do not predict the repeated implantation failure (RIF) for the in vitro fertilization patients. Genes Dis, 2020. 7(2): p. 283-289.

  2.3. Zeng, Q., L. Li, Y. Jin, Z. Chen, L. Duan, M. Cao, M. Ma, and Z. Wu, A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Paeonia lactiflora Pall. On the Treatment of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine, 2019: p. 8706589.

  2.4. Zeng, Q., L. Li, W. Siu, Y. Jin, M. Cao, W. Li, J. Chen, W. Cong, M. Ma, K. Chen, and Z. Wu, A combined molecular biology and network pharmacology approach to investigate the multi-target mechanisms of Chaihu Shugan San on Alzheimer's disease. Biomed Pharmacother, 2019. 120: p. 109370.

  2.5. Zhang, L., W. Hu, C.H. Cho, F.K. Chan, J. Yu, J.R. Fitzgerald, C.K. Cheung, Z.G. Xiao, J. Shen, L.F. Li, M.X. Li, J.C. Wu, T.K. Ling, J.Y. Chan, H. Ko, G. Tse, S.C. Ng, S. Yu, M.H. Wang, T. Gin, H. Ashktorab, D.T. Smoot, S.H. Wong, M.T. Chan, and W.K. Wu, Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. J Pathol, 2018. 244(4): p. 432-444.

  2.6. Li, M.X., Li, L.F., Zhang, L., Xiao, Z.G., Shen, J., Hu, W. & Cho, C.H. (2016). Vitamin D and cancer stem cells in the gastrointestinal tract. Curr. Med. Chem. 2017;24(9):918-927. (invited).

  2.7. Li, M.X., Li, L.F., Zhang, L., Hu, W., Shen, J., Xiao, Z.G., Chan, F.L., Cho, C.H. (2017). 1,25-Dihydroxyvitamin D3 suppresses cancer growth through VDR and mutant p53 in the induction of p21 expression in gastric cancer. Life Sciences 179 (2017) 88–97.

  2.8. Wong CC, Zhang L, Wu WK, Shen J, Chan RL, Lu L, Hu W, Li MX, Li LF, Ren SX, Li YF, Li J, Cho CH. Cathelicidin-encoding Lactococcus lactis promotes mucosal repair in murine experimental colitis. J Gastroenterol Hepatol. 2017;32(3):609-619.

  2.9. Zeng Q, Ko CH, Siu WS, Li LF, Han XQ, Yang L, Bik-San Lau C, Hu JM, Leung PC. Polysaccharides of Dendrobium officinale Kimura & Migo protect gastric mucosal cell against oxidative damage-induced apoptosis in vitro and in vivo. J Ethnopharmacol. 2017 Jul 4;208:214-224. 4

  2.10. Shen J, Li ZJ, Li LF, Lu L, Xiao ZG, Wu WK, Zhang L, Li MX, Hu W, Chan KM, Cho CH. (2016). Vascular-targeted TNFα and IFNγ inhibit orthotopic colorectal tumor growth. J. Translat. Med. 2016 24;14(1):187.

  2.11.Xiao ZG, Shen J, Zhang L, Li LF, Li MX, Hu W, Li ZJ, Cho CH. The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) in Cancers: Current Progress and Future Perspectives. Curr Med Chem. 2016;23(32):3687-3696.

  2.12. Shen J, Li WX, Xiao ZG, Zhang L, Li MX, Li LF, Hu W, Lu L, Boudreau F, Cho CH. The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. Curr Med Chem. 2016; 23(11):1131-8.

  2.13.Wang L, Hu T, Shen J, Zhang L, Li LF, Chan RL, Li MX, Wu WKK, Cho CH. (2016). Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. Life Sci, pii: S0024-3205(16)30134-5.

  2.14.Xu Z, Shen J, Wang MH, Yi T, Yu Y, Zhu Y, Chen B, Chen J, Li L, Li M, Zuo J, Jiang H, Zhou D, Luan J, Xiao Z. Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer. Oncoimmunology. 2016 Jul 11;5(8):e1207841.

  2.15.L. Lu, Z.J. Li, L.F. Li, W.K. Wu, J. Shen, L. Zhang, R.L. Chan, L. Yu, Y.W. Liu, S.X. Ren, K.M. Chan, C.H. Cho, Vascular-targeted TNFalpha improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer, J Control Release, 210 (2015) 134-46.

  2.16.Chan, B.C.L., Li, L.F., Hu, S.Q., Wat, E., Wong, E.C.W., et al. Gallic Acid Is the Major Active Component of Cortex Moutan in Inhibiting Immune Maturation of Human Monocyte-Derived Dendritic Cells. Molecules. 20 (2015), 16388-403.

  2.17.Hu, T., Li, L.F. & Cho, C.H. Chronic inflammation and colorectal cancer: the role of vascular endothelial growth factor. Curr. Pharmaceut. Design. 21 (2015), 2960-7.

  2.18.Luo KW, Yue GG, Ko CH, Lee JK, Gao S, Li LF, Li G, Fung KP, Leung PC, Lau CB, In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma. Phytomedicine. 21 (2014), 1078-87.

  二、会议论文

  1. Longfei Li, Linlin Wang, Lianghui Diao, Chunyu Huang, Yong Zeng. Maternal Hepatitis B Virus Infection Modulated Immune Cells Profiles in Endometrium from Women with Reproductive Failure. International Society for Immunology of Reproduction. Nov. 13-16, 2019, Nara Japan.

  2. Longfei Li, Linlin Wang, Chunyu Huang, Juanhua Wu, Yaya Wu and Yong Zeng. Immune profiles in the endometrium during implantation window and in the decidua of early pregnancy. Journal of Reproductive Immunology. 2018, 128: 57.

  3. Longfei Li, Linlin Wang, Yuanchang Zhu, Cong Chen, Juanhua Wu and Yong Zeng. Human placental Hofbauer cells are markedly decreased in spontaneous miscarriage. American Journal of Reproductive Immunology. 2018, 80 S1 P13.

  4. Linlin Wang, Longfei Li, Juanhua Wu, Cong Chen and Yong Zeng. Higher macrophages infiltration is correlated with poor outcome in early pregnancy. American Journal of Reproductive Immunology. 2018, 80 S1 P27.

  5. Long Fei Li, Lan Lu, Zhi Jie Li, Chi Hin Cho, “Can TCP-1, a peptide targeting colon cancer reduce the side effects of TNF-alpha?” Poster presentation in “Pan Pacific Symposium on Stem Cells and Cancer Research”, April 12-14, 2014, Taiwan. (Received Best Poster Presentation Award)

  6. Li LF, Yue GGL, Chen BCL, Lau CBS, Han QB, Liu JK, Leung PC and Fung KP, “In vitro investigations on the immunomodulatory activities of Rubinoboletus ballouii using human peripheral blood mononuclear cells.” Poster presentation in “6th International Functional Food Symposium”, October 25-26, 2012, Hong Kong. (Received Best Poster Presentation Award)

  7. Li LF, Yue GGL, Chen BCL, Lau CBS, Han QB, Liu JK, Leung PC and Fung KP, “Investigations on the immunomodulatory activities of Rubinoboletus ballouii using bioassay-guided fractionation”, Poster presentation in “The 8th International Postgraduate Symposium on Chinese Medicine 2012”, August 16, 2012, Hong Kong.

  8. Li LF, Yue GGL, Chen BCL, Lau CBS, Han QB, Liu JK, Leung PC and Fung KP, “Investigations on the in vitro immunomodulatory activities of Rubinoboletus ballouii using bioassay-guided fractionation”, Poster presentation in “The 7th International Postgraduate Symposium on Chinese Medicine 2011”, August 11, 2011, Hong Kong.

  9. Li LF, Lau CBS, Yue GGL, Han QB, Liu JK, Leung PC and Fung KP, “Investigations on the in vitro anti-tumor activities of Rubinoboletus ballouii”, Poster presentation in “The 9th Meeting of Consortium for Globalization of Chinese Medicine (CGCM)”, August 23-25, 2010, Hong Kong.

  10. Li LF, Yue GGL, Lau CBS, Han QB, Liu JK, Leung PC and Fung KP, “Investigations on the in vitro immunomodulatory activities of Rubinoboletus ballouii using human peripheral blood mononuclear cells”, Poster presentation in “6th Hong Kong-Macau Postgraduate Symposium on Chinese Medicine 2010”, August 12, 2010.

  三、专利

  1. 李龙飞, 王琳琳, 刁梁辉, 黄春宇, 李玉叶, 连若纯, 曾勇, 莫美兰, 陈聪, 一组胚胎反复种植失败的生物标志物、其筛选方法及应用. 申请号:202010363041.2,中国发明专利,2020.

  2. 李龙飞, 王琳琳, 刁梁辉, 黄春宇, 李玉叶, 连若纯, 曾勇, 莫美兰, 陈聪, 一组子宫内膜受容性的生物标志物、其筛选方法及应用. 申请号:202010363060.5,中国发明专利,2020.

  3. 吴彤华, 李龙飞, 宋明哲, 叶丽君, 陈春媚, 曾勇, 一种 piRNA 及用于检测和/或预测男性生殖功能障碍的试剂盒. 申请号:202010230867.1,中国发明专利,2020.

  4. 曹之宪, 李志杰, 李龙飞, 李明星, 肿瘤血管及M型巨噬细胞靶向肽及其用途.申请号:201711396421.0,中国发明专利,2017.

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