李玉叶
李玉叶

姓名:李玉叶
职称/头衔:博士 检验中心主任
所属科室:生殖科
从业年限:
技术专长:子宫内膜容受性的分子机制及免疫细胞及分子在复发性流产患者和反复种植患者的发病机制和临床应用

个人简介

  中山大学免疫学博士。深圳中山泌尿外科医院检验中心主任。
       擅长领域:慢性子宫内膜炎诊断标准与致病机制、子宫内膜免疫微环境预测指标及临床干预策略。
       社会任职:中国免疫学会生殖免疫分会第五届委员会委员、妇幼健康研究会生殖免疫学专业委员会委员、美国生殖免疫协会会员。

  学术成果:

  主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序):

  1、 深圳市自然科学基金、JCYJ20190803142103857、早孕期滋养细胞通过IDO-AhR诱导蜕膜CD8+T细胞PD-1表达的机制研究、2020/08-2023/08,10万,在研,主持。

  2、 国家自然科学基金青年项目、81601279、子宫内膜CD8+T细胞通过Fas通路促进滋养细胞侵袭的分子机制研究,2017/01-2019/12,17.5万,主持,结题。

  3、中华医学会临床医学科研专项资金、16020200636、子宫内膜CD8+T细胞对滋养层细胞调控机制的研究,2017/01-201912,11万,主持,结题。

  代表性研究成果和学术奖励

  一、期刊论文

  1. 第一作者或通讯作者论文

  (1)Li Yuye # ,Xu Shiru# , Yu Shuyi, Huang Chunyu, Lin Shenglai, Chen Wanru, Mo Meilan, Lian Ruochun, Diao Lianghui, Ding Lijun *, Zeng Yong *, Diagnosis of chronic endometritis: 2 How many CD138 + cells/HPF in endometrial stroma affect pregnancy outcome of infertile women? doi:10.1111 /aji.13369.(第一作者)

  (2) Diao, Lianghui(#), Songchen Cai(#), Chunyu Huang, Longfei Li, Shuyi Yu, Linlin Wang, Su Liu, Yuye Li(*), and Yong Zeng(*). New Endometrial Immune Cell-Based Score (Ei-Score) for the Prediction of Implantation Success for Patients Undergoing IVF/ICSI, Placenta (2020) 99, 180-188. (通讯作者)

  (3) Li Yuye(#), Yu Shuyi(#), Huang Chunyu, Lian Rruochun, Chen Cong, Liu Su, Li Longfei, Diao Lianghui, Udo R Markert(*), Zeng Yong(*). Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure. Fertil Steril 2019. (第一作者)

  (4) Yin Biao(#), Zeng Yong, Wu Tonghua, Yu Shuyi, Xu Jian, Liu Su, Diao Lianghui, Zhao Zhengfu, Desheng Liang(*), Li Yuye(*). Functional properties of peripheral CD8(+) T cells in patients with repeated implantation failure. Am J Reprod Immunol 2017;78.(通讯作者)

  (5) Li Yuye(#), Wu Siyu, Pu Jieying, et al. Dengue Virus Upregulates Expression of Notch Ligands Dll1 and Dll4 Through IFN- β Signaling Pathway. Immunology, 2015 Jan;144(1):127-38. (第一作者) (6) Zhang Peifen(#), Li Yuye(#), Xia Jiong, He Junfang, Pu Jieying, Xie Jiong et al. IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation. J Cell Sci 2014;127:2471-82.(第一作者)

  (7) Li Yuye(#), Xie Jiong, Wu Siyu, et al. Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsRNA-stimulated human lung epithelial cells. PLoS One 2013;8:e55108.(第一作者)

  2. 既非第一作者又非通讯作者论文

  (1) Liu S, Wei H, Li Y, Diao L, Lian R, Zhang X et al. Characterization of Dendritic Cell(DC)10 in recurrent miscarriage and recurrent implantation failure. Reproduction 2019.

  (2) Wei H, Liu S, Lian R, Huang C, Li Y, Chen L et al. Abnormal Expression of Indoleamine 2, 3-Dioxygenase in Human Recurrent Miscarriage. Reprod Sci 2019:1933719119833788.

  (3) Wang L, Li L, Huang C, Diao L, Lian R, Li Y et al. Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro 3 fertilization treatment. Fertil Steril 2019;112:250-7 e1.

  (4) Liu S, Wei H, Li Y, Huang C, Lian R, Xu J et al. Downregulation of ILT4(+) dendritic cells in recurrent miscarriage and recurrent implantation failure. Am J Reprod Immunol 2018;80:e12998.

  (5) Liu S, Diao L, Huang C, Li Y, Zeng Y, Kwak-Kim JYH. The role of decidual immune cells on human pregnancy. J Reprod Immunol 2017;124:44-53.

  (6) Pu J, Wu S, Xie H, Li Y, Yang Z, Wu X et al. miR-146a Inhibits dengue-virus-induced autophagy by targeting TRAF6. Arch Virol 2017;162:3645-59.

  (7) Pu J, He L, Xie H, Wu S, Li Y, Zhang P et al. Antiviral activity of Carbenoxolone disodium against dengue virus infection. J Med Virol 2017;89:571-81.

  (8) Xia J, Chen X, Xu F, Wang Y, Shi Y, Li Y et al. Dengue virus infection induces formation of G3BP1 granules in human lung epithelial cells. Arch Virol 2015;160:2991-9.

  (9) Wu S, He L, Li Y, Wang T, Feng L, Jiang L et al. miR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6. J Infect 2013;67:329-41.

  二、学术奖励

  “原因复发性流产患者免疫状态评估体系的建立” 深圳市科技进步奖 一等奖

  三、大会报告(大会口头报告)

  Li Yuye, Endometrial CD8+T cells testing in women with repeated implantation failure, The 38th Annual Meeting of the American Society for Reproductive Immunology, 上海, 2018-6-28 至 2018-7-1. (大会报告,并获得“John Gusdon Award”最佳口头报告奖。)

  四、授权专利

  (1)曾勇; 刁梁辉; 黄春宇; 李玉叶; 连若纯; 一种子宫血管阻断钳, 2020-3-31, 中国, ZL 2019 2 0201722. 1. (发明专利)

  (2)黄春宇; 刁梁辉; 陈现; 李玉叶; 连若纯; 陈聪; 一种用于评估子宫内膜容受性的试剂盒及其使用方法, 2017-10-31, 中国, ZL 2016 1 0021908. X. (发明专利)