研究方向：生殖免疫疾病发生发展机制及其治疗策略研究

　　擅长领域：干细胞及其来源的外泌体修复损伤子宫内膜中的作用及机制研究

　　学术任职：科研助理

　　学术成果：

　　一、主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序)：

　　1、深圳市自然科学基金-面上项目、JCYJ20230807150201003、脂肪酸结合蛋白3(FABP3)调控巨噬细胞脂滴平衡促进妊娠的分子机制研究、2024/01-2026/12，15万，在研，参与。

　　2、深圳市科创委基础研究项目：基 20220242 外泌体调控子宫内膜功能的机制及其与胎盘相关疾病关系研究(JCY20220818103207016)，(2022.10.28-2025.10.31)，在研，参与

　　二、代表性研究成果和学术奖励(分类按时间倒序排序)：

　　第一/共同第一作者发表的论文：

　　[1] Mingye Chen, Xunjia Ye, Xianhui He, Dongyun Ouyang, The Signaling Pathways Regulating NLRP3 Inflammasome Activation. Inflammation. 2021, 44(4): 1229-1245.

　　[2] [3] ChenGuang Li , MingYe Chen, XianHui He, DongYun Ouyang. A mini-review on ion fluxes that regulate NLRP3 inflammasome activation. Acta Biochim Biophys Sin (Shanghai). 2021;53(2):131-139

　　[3] Fan Yang, Xunjia Ye, Mingye Chen, Hongchun Li, Yaofeng Wang, Meiyan Zhong, Chunsu Zhong, Bo Zeng, Lihui Xu, Xianhui He, Dongyun Ouyang. Inhibition of NLRP3 Inflammasome Activation and Pyroptosis in Macrophages by Taraxasterol Is Associated With Its Regulation on mTOR Signaling. Front Immunol. 2021, 12632606.

　　[4] ChenGuang Li, QiongZhen Zeng, MingYe Chen, LiHui Xu, ChengCheng Zhang, FengYi Mai, ChenYing Zeng, XianHui He, DongYun Ouyang. Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation. Front Pharmacol, 2019, 10: 290.

　　既非第一作者又非通讯作者论文

　　[1] Xian Chen; Lingbin Qi; Chenyang Zhao; Jinfeng Xue; Mingye Chen; Lianghui Diao; Wen He; Bo Lv; Yong Zeng; Zhigang Xue ; Decreased expression of SEMA4D induces reduction of trophoblast invasion and migration via the Met/PI3K/Akt pathway in recurrent implantation failure, Journal of Reproductive Immunology, 2022, 153: 103657-103657.

　　[2] Meiyan Zhong, Yuanting Huang, Bo Zeng, Lihui Xu, Chunsu Zhong, Jiahao Qiu, Xunjia Ye, Mingye Chen, Bo Hu, Dongyun Ouyang, Xianhui He. Induction of multiple subroutines of regulated necrosis in murine macrophages by natural BH3-mimetic gossypol. Acta Biochimica et Biophysica Sinica, 2022, 54(1): 64-76.

　　[3] Ye XJ, Xu R, Liu SY, Hu B, Shi ZJ, Shi FL, Zeng B, Xu LH, Huang YT, Chen MY, Zha QB, He XH, Ouyang DY. Taraxasterol mitigates Con A-induced hepatitis in mice by suppressing interleukin-2 expression and its signaling in T lymphocytes. Int Immunopharmacol. 2022 Jan;102:108380.